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Home > Products >  1-Cyclopropyl-2-(2-fluorophenyl)ethanone CAS NO.150322-73-9

1-Cyclopropyl-2-(2-fluorophenyl)ethanone CAS NO.150322-73-9 CAS NO.150322-73-9

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Keywords

  • Cyclopropyl 2-fluorobenzyl ketone
  • 1-CYCLOPROPYL-2-(2-FLUORO-PHENYL)-ETHANONE
  • Prasugrel intermediate

Quick Details

  • ProName: 1-Cyclopropyl-2-(2-fluorophenyl)ethano...
  • CasNo: 150322-73-9
  • Molecular Formula: C11H11FO
  • Appearance: Colorless or light yellow transparent ...
  • Application: Pharmaceutical intermediate
  • PackAge: Fluoride bottle
  • ProductionCapacity: Metric Ton/Day
  • Purity: NLT98.0%
  • Storage: Room temperature
  • LimitNum: 0 Metric Ton

Superiority

Prasugrel is by Eli Lilly and Japanese drugmaker Daiichi Sankyo company (DaiichiSankyo) development of thienopyridine antiplatelet drug, is a pro drug, in the liverby cytochrome P450 metabolism after the formation of active molecules, bindingand platelet P2Y12 receptor and exert antiplatelet aggregation activity. Clinical studies demonstrate that, compared with the 60 mg dose clopidogrel 300 mg and 600 mg of standard dose increased dose has better anti clotting effect, can make the patient of heart attack, stroke, heart disease deaths due to comprehensive riskis reduced by 20%, and quick effect, good curative effect, use drug resistance andgood bioavailability, toxicity is low.

Prasugrel in stable angina and acute coronary syndrome interventional operation is also stronger than clopidogrel antiplatelet effect is more strong, but also more easily cause bleeding. The key question now is how we identify thrombosis risk in clinical patients, and how to identify the risk of hemorrhage of high-risk groups,which can make the difference between Prager Ray and clopidogrel use in twohigh-risk groups, both to reduce coronary thrombosis and avoid major bleeding. In December 18, 2008, prasugrel obtained its first major international accreditation,the European Medicines Agency Europeans for Medical Products Committee(CHMP) to recommend approval of the drug.

In late February 2009 by the European Commission's permission. In Europe, sold under the brand name Efient, used in the treatment of acute coronary syndrome.The working principle of prasugrel is adopted in the platelet surface prevents P2Y12 adenosine two phosphate receptor and inhibit platelet activation andaggregation of concurrent. Antiplatelet drugs used to prevent platelet aggregationor glued together, if platelet aggregation can lead to clogged arteries and maycause a heart attack or stroke.

In July 10, 2009 American approved by the food and drug administration receivedprasugrel tablets for angioplasty patients, in order to reduce the risk of blood clots.

In 2010 April in Canada approved, for the treatment of acute coronary syndrome.

Prasugrel tag has boxed warnings, remind the doctor the drug may cause the obvious, sometimes fatal bleeding. This product should not be used for the following patients: current pathological hemorrhage; a history of stroke or transient ischemic attack; or the need for emergency operation, including coronary artery bypass operation

Details

ANGELISUN is a group company integrates research,production and sale. It consists of Angelisun Pharmaceutical Co., LTD. Chongqing An Ge Long Xiang Pharmaceutical Co., LTD. Angelisun(Chongqing)Pharmaceutical Co., LTD.

Main Research Project

anti-tumor and cardiovascular drugs

discovery and research of new drugs (including synthesis, preparation and quality control)

custom synthesis , counseling service, applicant and register (including drugs , intermediates)

Our Team

Angelisun is managed by a team of skilled and experienced professionals. They are all outstanding person in pharmaceutical and synthetic industries. Their collective efforts contribute to a significant development of Angelisun. Now we are of a team with mass production and mature analytical skills, together with professional project management and excellent customer service.

Insisting on surviving on quality and developing on technology, we sincerely hope to establish cooperative relationships with friends at home and abroad for beautiful future.

Our Collaborator

SIMM(Shanghai Institute of Materia Medica)

ChongqingUniversity

ChongqingMedical University

SouthwestUniversity

FudanUniversity

ShenyangPharmaceutical University

Our Mission

With our supply of health care products, the quality of life will be improved.

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